Functional Consequence of Positive Selection Revealed through Rational Mutagenesis of Human Myeloperoxidase
نویسندگان
چکیده
منابع مشابه
Functional consequence of positive selection revealed through rational mutagenesis of human myeloperoxidase.
Myeloperoxidase (MPO) is a member of the mammalian heme peroxidase (MHP) multigene family. Whereas all MHPs oxidize specific halides to generate the corresponding hypohalous acid, MPO is unique in its capacity to oxidize chloride at physiologic pH to produce hypochlorous acid (HOCl), a potent microbicide that contributes to neutrophil-mediated host defense against infection. We have previously ...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2012
ISSN: 1537-1719,0737-4038
DOI: 10.1093/molbev/mss073